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  • Rabbit anti-SIGLEC12 Polyclonal Antibody

    促销商品
    • SIGLEC12抗体,S2V,Siglec-XII,SIGLECL1,SLG
    货号: abs118547
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs118547-50ul 1-2周 ¥1500.00 ¥1050.00
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    大包装询价
    概述
    别名
    SIGLEC12抗体;S2V,Siglec-XII,SIGLECL1,SLG
    宿主
    Rabbit
    反应种属
    Mouse
    应用
    WB 1:500 - 1:2000
    分子量
    Detects a band of approximately 80kD (Predicted molecular weight: 51kD/64kD)
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 20-210 of human SIGLEC12 (NP_443729.1).
    阳性对照
    Mouse spleen,Mouse heart
    性能
    纯化方法
    Affinity purification
    类型
    Polyclonal Antibody
    同种型
    IgG
    储存/保存方法
    Store at -20℃. Avoid freeze / thaw cycles.
    存储溶液
    Store at -20℃. Avoid freeze / thaw cycles.
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    靶标
    背景说明
    Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
    细胞定位
    Membrane,Single-pass type I membrane protein
    UniProt
    Western blot analysis of extracts of various cell lines, using SIGLEC12 antibody (abs118547) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 90s.
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    • 实验方法 实验条件
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