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  • Rabbit anti-SIAH1 Polyclonal Antibody

    • SIAH1抗体;E3 ubiquitin-protein ligase SIAH1, FLJ08065, hSIAH1, HUMSIAH, Seven in absentia homolog 1 (Drosophila), Seven in absentia homolog 1, Siah 1, Siah 1a, Siah E3 ubiquitin protein ligase 1, Siah-1, Siah-1a, Siah1, SIAH1_HUMAN, SIAH1A, Ubiquitin ligase SIAH1, E3 ubiquitin protein ligase SIAH2, E3 ubiquitin-protein ligase SIAH1, hSIAH1, hSiah2, HUMSIAH, Seven in absentia homolog 1 (Drosophila), Seven in absentia homolog 1, Seven in Absentia Homolog 2, SIAH 1, Siah 1a, Siah 2, Siah-1, Siah-1a, Siah1, SIAH1_HUMAN, Ubiquitin ligase SIAH1, Ubiquitin Ligase Siah2,
    货号: abs133643
    产品说明书
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    货号-规格 货期 价格 数量
    abs133643-50ug 1-2周 ¥1500.00
    - +
    abs133643-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    SIAH1抗体;E3 ubiquitin-protein ligase SIAH1, FLJ08065, hSIAH1, HUMSIAH, Seven in absentia homolog 1 (Drosophila), Seven in absentia homolog 1, Siah 1, Siah 1a, Siah E3 ubiquitin protein ligase 1, Siah-1, Siah-1a, Siah1, SIAH1_HUMAN, SIAH1A, Ubiquitin ligase SIAH1, E3 ubiquitin protein ligase SIAH2, E3 ubiquitin-protein ligase SIAH1, hSIAH1, hSiah2, HUMSIAH, Seven in absentia homolog 1 (Drosophila), Seven in absentia homolog 1, Seven in Absentia Homolog 2, SIAH 1, Siah 1a, Siah 2, Siah-1, Siah-1a, Siah1, SIAH1_HUMAN, Ubiquitin ligase SIAH1, Ubiquitin Ligase Siah2,
    宿主
    Rabbit
    特异性
    SIAH1 Antibody detects endogenous levels of total SIAH1.
    反应种属
    Human;Mouse;Rat
    应用
    WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 34KD
    免疫原
    A synthesized peptide derived from Human SIAH1(Accession Q8IUQ4), corresponding to amino acid residues M1-T29.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
    组织特异性
    Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas.
    翻译后修饰
    Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2.
    细胞定位
    Cytosol;Endosome;Nucleus;Plasma Membrane;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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