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  • Rabbit anti-PHF1 Polyclonal Antibody

    • PHF1抗体,hPCl1, MTF2 L2, MTF2L 2, MTF2L2, PCL 1, PCL1, PHD finger protein 1, PHD finger protein1, PHF 1, PHF 2, Phf1, PHF1_HUMAN, PHF2, Plc 1, Plc1, Polycomb like protein 1, Polycomb like protein1, Polycomb-like protein 1, Protein PHF1, T complex testis expressed 3, T complex testis expressed3, Tctex 3, Tctex3,
    货号: abs133322
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs133322-50ug 1-2周 ¥1500.00
    - +
    abs133322-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    PHF1抗体;hPCl1, MTF2 L2, MTF2L 2, MTF2L2, PCL 1, PCL1, PHD finger protein 1, PHD finger protein1, PHF 1, PHF 2, Phf1, PHF1_HUMAN, PHF2, Plc 1, Plc1, Polycomb like protein 1, Polycomb like protein1, Polycomb-like protein 1, Protein PHF1, T complex testis expressed 3, T complex testis expressed3, Tctex 3, Tctex3,
    宿主
    Rabbit
    特异性
    PHF1 Antibody detects endogenous levels of total PHF1.
    反应种属
    Human;Mouse;Rat
    预测反应种属
    Rabbit
    应用
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 62KD
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthesized peptide derived from Human PHF1(Accession O43189), corresponding to amino acid residues E372-P397.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
    组织特异性
    Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney.
    细胞定位
    Cytoskeleton;Nucleus;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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