Rabbit anti-Maf Polyclonal Antibody

Maf抗体;AS42 oncogene homolog, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene, Avian musculoaponeurotic fibrosarcoma (v maf), c maf proto oncogene, cMaf, maf, MAF_HUMAN, MAF2, MGC71685, Proto oncogene c Maf, Proto-oncogene c-maf, Transcription factor Maf, v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian), v maf musculoaponeurotic fibrosarcoma oncogene homolog, V-maf musculoaponeurotic fibrosarcoma oncogene homolog,

Rabbit

Maf Antibody detects endogenous levels of total Maf.

Human;Mouse;Rat

Pig;Zebrafish;Chicken;Sheep;Bovine

WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Predicted molecular weight: 38kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

A synthesized peptide derived from Human MAF(Accession O75444), corresponding to amino acid residues L330-E349.

1mg/ml

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .

Polyclonal Antibody

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Expressed in endothelial cells.

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids.Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable). The phosphorylation status can serve to either stimulate or inhibit transcription.

Nucleus;