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  • Rabbit anti-HGS Polyclonal Antibody

    • HGS抗体,Hepatocyte growth factor regulated tyrosine kinase substrate, Hepatocyte growth factor-regulated tyrosine kinase substrate, HGF-regulated tyrosine kinase substrate, HGNC:4897, HGS, HGS_HUMAN, Hrs, Human growth factor regulated tyrosine kinase substrate, Protein pp110, ZFYVE8,
    货号: abs133317
    产品说明书
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    货号-规格 货期 价格 数量
    abs133317-50ug 1-2周 ¥1500.00
    - +
    abs133317-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    HGS抗体;Hepatocyte growth factor regulated tyrosine kinase substrate, Hepatocyte growth factor-regulated tyrosine kinase substrate, HGF-regulated tyrosine kinase substrate, HGNC:4897, HGS, HGS_HUMAN, Hrs, Human growth factor regulated tyrosine kinase substrate, Protein pp110, ZFYVE8,
    宿主
    Rabbit
    特异性
    HGS Antibody detects endogenous levels of total HGS.
    反应种属
    Human;Mouse;Rat
    应用
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 86kD
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthesized peptide derived from Human HGS(Accession O14964), corresponding to amino acid residues I322-S345.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
    组织特异性
    Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
    翻译后修饰
    Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.Ubiquitinated by ITCH.
    细胞定位
    Cytosol;Endosome;Extracellular region or secreted;Lysosome;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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