Rabbit anti-HGS Polyclonal Antibody
- HGS抗体,Hepatocyte growth factor regulated tyrosine kinase substrate, Hepatocyte growth factor-regulated tyrosine kinase substrate, HGF-regulated tyrosine kinase substrate, HGNC:4897, HGS, HGS_HUMAN, Hrs, Human growth factor regulated tyrosine kinase substrate, Protein pp110, ZFYVE8,
货号: abs133317
货号-规格 | 货期 | 价格 | 数量 |
abs133317-50ug | 1-2周 | ¥1500.00 | - + |
abs133317-100ug | 1-2周 | ¥2300.00 | - + |

概述 | |
别名 | HGS抗体;Hepatocyte growth factor regulated tyrosine kinase substrate, Hepatocyte growth factor-regulated tyrosine kinase substrate, HGF-regulated tyrosine kinase substrate, HGNC:4897, HGS, HGS_HUMAN, Hrs, Human growth factor regulated tyrosine kinase substrate, Protein pp110, ZFYVE8, |
宿主 | Rabbit |
特异性 | HGS Antibody detects endogenous levels of total HGS. |
反应种属 | Human;Mouse;Rat |
应用 | WB 1:1000-3000, IHC 1:200, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000 |
分子量 | Predicted molecular weight: 86kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 | A synthesized peptide derived from Human HGS(Accession O14964), corresponding to amino acid residues I322-S345. |
性能 | |
浓度 | 1mg/ml |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 | Polyclonal Antibody |
储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
靶标 | |
背景说明 | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
组织特异性 | Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. |
翻译后修饰 | Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF.Ubiquitinated by ITCH. |
细胞定位 | Cytosol;Endosome;Extracellular region or secreted;Lysosome; |
UniProt | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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