Rabbit anti-GPR56 Polyclonal Antibody
- GPR56抗体,7 transmembrane protein with no EGF like N terminal domains 1, BFPP, DKFZp781L1398, EGF TM7 like, G protein coupled receptor 56, G-protein coupled receptor 56, GPR 56, Gpr56, GPR56_HUMAN, Polymicrogyria bilateral frontoparietal, Protein TM7XN1, TM7LN4, TM7XN1, TM7XN1 protein,
货号: abs133132
货号-规格 | 货期 | 价格 | 数量 |
abs133132-50ug | 1-2周 | ¥1500.00 | - + |
abs133132-100ug | 1-2周 | ¥2300.00 | - + |

概述 | |
描述 | Could be involved in cell-cell interactions |
别名 | GPR56抗体;7 transmembrane protein with no EGF like N terminal domains 1, BFPP, DKFZp781L1398, EGF TM7 like, G protein coupled receptor 56, G-protein coupled receptor 56, GPR 56, Gpr56, GPR56_HUMAN, Polymicrogyria bilateral frontoparietal, Protein TM7XN1, TM7LN4, TM7XN1, TM7XN1 protein, |
宿主 | Rabbit |
特异性 | GPR56 antibody detects endogenous levels of total GPR56. |
反应种属 | Human |
预测反应种属 | Sheep;Horse;Pig |
应用 | WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000 |
分子量 | Predicted molecular weight: 78kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 | A synthesized peptide derived from Human ADGRG1(Accession Q9Y653), corresponding to amino acid residues G668-I693. |
性能 | |
浓度 | 1mg/ml |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 | Polyclonal Antibody |
储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
靶标 | |
背景说明 | Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity). |
组织特异性 | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. |
翻译后修饰 | Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s) (PubMed:22333914).N-glycosylated. Contains sialic acid residues.Ubiquitinated. Undergoes polyubiquitination upon activation. |
细胞定位 | Extracellular region or secreted;Plasma Membrane; |
UniProt | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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- GPR56 promotes proliferation of colorectal cancer cells and enhances metastasis via epithelial‑mesenchymal transition through PI3K/AKT signaling activation
Bing Ji,Yifei Feng,Ye Sun,Dongjian Ji,Wenwei Qian,Zhiyuan Zhang,Qingyuan Wang,Yue Zhang,Chuan Zhang,Yueming Sun
oncology reports. 2018 Jul 20 ; 4
影响因子: 2.976
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