Rabbit anti-GPR56 Polyclonal Antibody
- GPR56抗体,7 transmembrane protein with no EGF like N terminal domains 1, BFPP, DKFZp781L1398, EGF TM7 like, G protein coupled receptor 56, G-protein coupled receptor 56, GPR 56, Gpr56, GPR56_HUMAN, Polymicrogyria bilateral frontoparietal, Protein TM7XN1, TM7LN4, TM7XN1, TM7XN1 protein,
Could be involved in cell-cell interactions
GPR56抗体;7 transmembrane protein with no EGF like N terminal domains 1, BFPP, DKFZp781L1398, EGF TM7 like, G protein coupled receptor 56, G-protein coupled receptor 56, GPR 56, Gpr56, GPR56_HUMAN, Polymicrogyria bilateral frontoparietal, Protein TM7XN1, TM7LN4, TM7XN1, TM7XN1 protein,
GPR56 antibody detects endogenous levels of total GPR56.
WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Predicted molecular weight: 78kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
A synthesized peptide derived from Human ADGRG1(Accession Q9Y653), corresponding to amino acid residues G668-I693.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).
Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.
Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s) (PubMed:22333914).N-glycosylated. Contains sialic acid residues.Ubiquitinated. Undergoes polyubiquitination upon activation.
Extracellular region or secreted;Plasma Membrane;
- 实验方法 实验条件
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- GPR56 promotes proliferation of colorectal cancer cells and enhances metastasis via epithelial‑mesenchymal transition through PI3K/AKT signaling activation
Bing Ji,Yifei Feng,Ye Sun,Dongjian Ji,Wenwei Qian,Zhiyuan Zhang,Qingyuan Wang,Yue Zhang,Chuan Zhang,Yueming Sun
oncology reports. 2018 Jul 20 ; 4