Rabbit anti-GNE Polyclonal Antibody
- GNE抗体,DMRV; GLCNE; IBM2; NM; Uae1
货号: abs118574
货号-规格 | 货期 | 价格 | 数量 |
abs118574-50ul | 1-2周 | ¥1500.00 | - + |

概述 | ||
别名 | GNE抗体;DMRV; GLCNE; IBM2; NM; Uae1 | |
宿主 | Rabbit | |
反应种属 | Human, Mouse, Rat | |
应用 | WB 1:500 - 1:2000 IHC 1:50 - 1:100 | |
分子量 | Detects a band of approximately 79kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. | |
免疫原 | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GNE (NP_001121699.1). | |
阳性对照 | LO2,SW480,A-549,Jurkat,HeLa,Mouse liver,Mouse lung,Mouse kidney,Rat liver | |
性能 | ||
纯化方法 | Affinity purification | |
类型 | Polyclonal Antibody | |
同种型 | IgG | |
储存/保存方法 | Store at -20℃. Avoid freeze / thaw cycles. | |
存储溶液 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | |
靶标 | ||
背景说明 | The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. | |
细胞定位 | Cytoplasm | |
UniProt | ||
Western blot analysis of extracts of various cell lines, using GNE antibody (abs118574) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 30s. | ||
Immunohistochemistry of paraffin-embedded mouse brain using GNE antibody at dilution of 1:100 (40x lens). | ||
Immunohistochemistry of paraffin-embedded rat brain using GNE antibody at dilution of 1:100 (40x lens). | ||
Immunohistochemistry of paraffin-embedded human colon using GNE antibody at dilution of 1:100 (40x lens). | ||
Immunohistochemistry of paraffin-embedded human esophagus using GNE antibody at dilution of 1:100 (40x lens). | ||
Immunohistochemistry of paraffin-embedded human stomach using GNE antibody at dilution of 1:100 (40x lens). | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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