Rabbit anti-DYR1B Polyclonal Antibody

DYR1B抗体;AOMS3, Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B, Dual specificity tyrosine phosphorylation regulated kinase 1B, Dual specificity tyrosine-phosphorylation-regulated kinase 1B, DYR 1B, DYR1A, DYR1B, DYR1B_HUMAN, DYRK 1B, Dyrk1b, Minibrain related kinase, Minibrain-related kinase, MIRK, Mirk protein kinase,

Rabbit

DYR1B Antibody detects endogenous levels of total DYR1B.

Human;Mouse

Rabbit;Pig;Dog;Bovine;

WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Predicted molecular weight: 70KD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

A synthesized peptide derived from Human DYRK1B(Accession Q9Y463), corresponding to amino acid residues Y346-R374.

1mg/ml

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .

Polyclonal Antibody

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.

Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.

Nucleus;