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  • Rabbit anti-DROSHA Polyclonal Antibody

    • DROSHA抗体;ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN
    货号: abs118419
    产品说明书
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    货号-规格 货期 价格 数量
    abs118419-50ul 1-2周 ¥1500.00
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    大包装询价
    概述
    别名
    DROSHA抗体;ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN
    宿主
    Rabbit
    反应种属
    Human
    应用
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
    分子量
    Detects a band of approximately 159kD
    免疫原
    A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DROSHA (NP_037367.3).
    阳性对照
    K-562
    性能
    纯化方法
    Affinity purification
    类型
    Polyclonal Antibody
    同种型
    IgG
    储存/保存方法
    Store at -20℃. Avoid freeze / thaw cycles.
    存储溶液
    Store at -20℃. Avoid freeze / thaw cycles.
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    靶标
    背景说明
    This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
    细胞定位
    Nucleus,nucleolus
    UniProt
    Western blot analysis of extracts of K-562 cells, using DROSHA antibody (abs118419) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 90s.
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    • 实验方法 实验条件
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