Rabbit anti-CYP46A1 Polyclonal Antibody

CYP46A1抗体;CP46,CYP46

Rabbit

Human;Mouse;Rat

WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:100

Detects a band of approximately 57kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1).

U-87MG,U-251MG,MCF-7,Mouse liver,Mouse brain,Rat liver

Affinity purification

Polyclonal Antibody

IgG

Store at -20℃. Avoid freeze / thaw cycles.

Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Endoplasmic reticulum membrane,Microsome membrane,Single-pass membrane protein