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  • Rabbit anti-CLASP2 Polyclonal Antibody
  • CLAP2_HUMAN; Clasp2; CLIP associated protein 2; CLIP associating protein 2; CLIP-associating protein 2; Cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; hOrbit2; KIAA0627; Multiple asters (Mast) like homolog 2; Protein Orbit homolog 2;
  • 货号: abs138918
    产品说明书
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    货号-规格 货期 价格 数量
    abs138918-50ug 1-2周 ¥1100.00
    - +
    abs138918-100ug 1-2周 ¥1650.00
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    大包装询价
    概述
    别名
    CLAP2_HUMAN; Clasp2; CLIP associated protein 2; CLIP associating protein 2; CLIP-associating protein 2; Cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; hOrbit2; KIAA0627; Multiple asters (Mast) like homolog 2; Protein Orbit homolog 2;
    宿主
    Rabbit
    特异性
    CLASP2 Antibody detects endogenous levels of total CLASP2.
    反应种属
    Human
    预测反应种属
    Rabbit;Pig;Dog;Horse;
    应用
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    免疫原
    A synthesized peptide derived from human CLASP2.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
    组织特异性
    Brain-specific.
    翻译后修饰
    Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.
    细胞定位
    Cytoskeleton;Cytosol;Golgi apparatus;Plasma Membrane;
    UniPort
    Western blot analysis CLASP2 using COS7 whole cell lysates
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