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  • Rabbit anti-CKII alpha (CSNK2A1) (Center) Polyclonal Antibody
  • Casein kinase II subunit alpha, CK II alpha, CSNK2A1, CK2A1;CSNK2A1;CK2A1
  • 货号: abs111567
    产品说明书
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    货号-规格 货期 价格 数量
    abs111567-50ul 1-2周 ¥1250.00
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    大包装询价
    概述
    描述
    Purified Rabbit Polyclonal Antibody (Pab)
    别名
    Casein kinase II subunit alpha, CK II alpha, CSNK2A1, CK2A1;CSNK2A1;CK2A1
    宿主
    Rabbit
    特异性
    This CKII alpha (CSNK2A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the Central region of human CKII alpha (CSNK2A1).
    反应种属
    Human;Mouse;Rat
    预测反应种属
    B, C, Rb, R, X
    应用
    WB~~1:2000
    IHC-P~~1:50~100
    性能
    类型
    Polyclonal Antibody
    同种型
    Rabbit Ig
    储存/保存方法
    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    存储溶液
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    研究领域
    Cancer;Cell Biology;Signal Transduction
    靶标
    背景说明
    Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.
    UniPort
    P68400
    参考文献
    参考文献
    Miyata, Y., et al., Mol. Cell. Biol. 24(9):4065-4074 (2004).
    Loizou, J.I., et al., Cell 117(1):17-28 (2004).
    Filhol, O., et al., EMBO Rep. 5(4):351-355 (2004).
    Kulartz, M., et al., Biochem. Biophys. Res. Commun. 315(4):1011-1017 (2004).
    Sachs, N.A., et al., J. Neurochem. 88(1):51-62 (2004).
    All lanes : Anti-CSNK2A1 Antibody (Y255) at 1:2000 dilution Lane 1: C6 whole cell lysates Lane 2: MOLT-4 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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