AU019445; AW742964; Cbp/p300 interacting transactivator 4; cbp/p300 interacting transactivator, with glu/asp rich carboxy terminal domain, 4; Cbp/p300-interacting transactivator 4; CITE4_HUMAN; Cited4; MRG 2; MRG-2; Mrg2; MSG1 related protein 2; MSG1-related protein 2; Transcriptional co-activator 4;
CITED4 antibody detects endogenous levels of total CITED4.
WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
A synthesized peptide.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis.
|Western blot analysis of CITED4 expression in MCF7 Cell Lysate ,The lane on the left is treated with the antigen-specific peptide.|
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