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  • Rabbit anti-CIRBP (C-term) Polyclonal Antibody
  • Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP;CIRBP;A18HNRNP, CIRP
  • 货号: abs111861
    产品说明书
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    货号-规格 货期 价格 数量
    abs111861-50ul 1-2周 ¥1250.00
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    大包装询价
    概述
    描述
    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
    别名
    Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP;CIRBP;A18HNRNP, CIRP
    宿主
    Rabbit
    特异性
    This CIRBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP.
    反应种属
    Human
    预测反应种属
    Ha, M, R
    应用
    WB~~1:1000
    IHC-P~~1:50~100
    性能
    类型
    Polyclonal Antibody
    同种型
    Rabbit Ig
    储存/保存方法
    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    存储溶液
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
    研究领域
    Cell Biology
    靶标
    背景说明
    Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
    细胞定位
    Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
    UniPort
    Q14011
    参考文献
    参考文献
    Colinge J., et.al., Submitted (OCT-2008) to UniProtKB.
    Yang R.,et.al., Nucleic Acids Res. 34:1224-1236(2006).
    Western blot analysis of CIRBP Antibody (C-term) (Cat. #abs111861) in Y79 cell line lysates (35ug/lane). CIRBP (arrow) was detected using the purified Pab.
    CIRBP Antibody (C-term) (Cat. #abs111861) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIRBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    Western blot analysis of CIRBP (arrow) using rabbit polyclonal CIRBP Antibody (C-term) (Cat. #abs111861). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CIRBP gene.
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