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  • Rabbit anti-CIITA Polyclonal Antibody
  • C2TA; C2TA_HUMAN; CIITA; CIITA IV; Class II major histocompatibility complex transactivator; Class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing;
  • 货号: abs133459
    产品说明书
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    货号-规格 货期 价格 数量
    abs133459-50ug 1-2周 ¥1100.00
    - +
    abs133459-100ug 1-2周 ¥1650.00
    - +
    大包装询价
    概述
    别名
    C2TA; C2TA_HUMAN; CIITA; CIITA IV; Class II major histocompatibility complex transactivator; Class II transactivator; MHC class II transactivator; MHC class II transactivator type III; MHC2TA; NLR family acid domain containing; NLRA; Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing;
    宿主
    Rabbit
    特异性
    CIITA Antibody detects endogenous levels of total CIITA.
    反应种属
    Human;Mouse;Rat
    预测反应种属
    Pig;Rabbit;Sheep;Dog;Bovine;Horse;
    应用
    WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    免疫原
    A synthesized peptide.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).
    翻译后修饰
    Autophosphorylated, affecting interaction with TAF7.
    细胞定位
    Nucleus;
    UniPort
    Western blot analysis of extracts from K562 cells, using CIITA antibody.
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