首页 产品中心
  • Rabbit anti-CIDEC (Center) Polyclonal Antibody
  • Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27 homolog, CIDEC, FSP27;CIDEC;FSP27
  • 货号: abs103436
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs103436-50ul 1-2周 ¥1250.00
    - +
    大包装询价
    概述
    描述
    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
    别名
    Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27 homolog, CIDEC, FSP27;CIDEC;FSP27
    宿主
    Rabbit
    特异性
    This CIDEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CIDEC.
    反应种属
    Human
    应用
    WB~~1:1000
    性能
    类型
    Polyclonal Antibody
    同种型
    Rabbit Ig
    储存/保存方法
    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    存储溶液
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
    研究领域
    Cardiovascular;Cell Biology
    靶标
    背景说明
    Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
    细胞定位
    Nucleus. Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites
    UniPort
    参考文献
    参考文献
    Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)
    Nian, Z., et al. J. Biol. Chem. 285(13):9604-9615(2010)
    Hall, A.M., et al. Obesity (Silver Spring) 18(2):417-419(2010)
    Rubio-Cabezas, O., et al. EMBO Mol Med 1(5):280-287(2009)
    Magnusson, B., et al. Metab. Clin. Exp. 57(9):1307-1313(2008)
    CIDEC Antibody (Center) (Cat. #abs103436) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CIDEC antibody detected the CIDEC protein (arrow).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
        提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要提问”按钮填写您的疑问。
        提交不成功?请联系info@absin.cn。
        我要提问

    促销资讯 更多

      订购信息
      您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
      GO
      • 0