Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, Fat-specific protein FSP27 homolog, CIDEC, FSP27；CIDEC；FSP27
This CIDEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CIDEC.
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Nucleus. Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites
Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)
Nian, Z., et al. J. Biol. Chem. 285(13):9604-9615(2010)
Hall, A.M., et al. Obesity (Silver Spring) 18(2):417-419(2010)
Rubio-Cabezas, O., et al. EMBO Mol Med 1(5):280-287(2009)
Magnusson, B., et al. Metab. Clin. Exp. 57(9):1307-1313(2008)
|CIDEC Antibody (Center) (Cat. #abs103436) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CIDEC antibody detected the CIDEC protein (arrow).|
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