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  • Rabbit anti-CIDEA (C-term) Polyclonal Antibody
  • Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA;CIDEA
  • 货号: abs102130
    产品说明书
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    货号-规格 货期 价格 数量
    abs102130-50ul 1-2周 ¥1250.00
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    大包装询价
    概述
    描述
    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
    别名
    Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA;CIDEA
    宿主
    Rabbit
    特异性
    This CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human CIDEA.
    反应种属
    Human
    应用
    WB~~1:1000
    性能
    类型
    Polyclonal Antibody
    同种型
    Rabbit Ig
    储存/保存方法
    Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    存储溶液
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
    研究领域
    Cardiovascular;Cell Biology;Metabolism
    靶标
    背景说明
    Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
    细胞定位
    Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062) {ECO:0000250, ECO:0000269|PubMed:18509062}
    UniPort
    参考文献
    参考文献
    Li, F., et al. FEBS J. 277(20):4173-4183(2010)
    Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)
    Huang, Y.W., et al. Gynecol. Oncol. 117(2):239-247(2010)
    Laurencikiene, J., et al. Cancer Res. 68(22):9247-9254(2008)
    Valouskova, E., et al. Gen. Physiol. Biophys. 27(2):92-100(2008)
    CIDEA Antibody (C-term) (Cat. #abs102130) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CIDEA antibody detected the CIDEA protein (arrow).
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