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  • Rabbit anti-CDK6 Polyclonal Antibody

    促销商品
    • CDK6抗体,MCPH12,PLSTIRE
    货号: abs133829
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs133829-50ul 1-2周 ¥1500.00 ¥1050.00
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    大包装询价
    概述
    别名
    CDK6抗体;MCPH12,PLSTIRE
    宿主
    Rabbit
    反应种属
    Human;Mouse;Rat
    应用
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    分子量
    Detects a band of approximately 37kD (Predicted molecular weight: 36kD)
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthetic peptide of human CDK6
    阳性对照
    Jurkat,Mouse liver,Rat brain
    性能
    纯化方法
    Affinity purification
    类型
    Polyclonal Antibody
    同种型
    IgG
    储存/保存方法
    Store at -20℃. Avoid freeze / thaw cycles.
    存储溶液
    Store at -20℃. Avoid freeze / thaw cycles.
    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    靶标
    背景说明
    The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    细胞定位
    Cell projection,Cytoplasm,Nucleus,centrosome,cytoskeleton,microtubule organizing center,ruffle
    UniProt
    Western blot analysis of extracts of various cell lines, using CDK6 antibody (abs133829) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 90s.
    Immunohistochemistry of paraffin-embedded human brain cancer using CDK6 antibody at dilution of 1:100 (40x lens).
    Immunohistochemistry of paraffin-embedded human gastric cancer using CDK6 antibody at dilution of 1:100 (40x lens).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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