Rabbit anti-CACNA2D2 Polyclonal Antibody
- CACNA2D2抗体,CACNA2D
货号: abs133869
货号-规格 | 货期 | 价格 | 数量 |
abs133869-50ul | 1-2周 | ¥1500.00 | - + |

概述 | |
别名 | CACNA2D2抗体;CACNA2D |
宿主 | Rabbit |
反应种属 | Mouse;Rat |
应用 | WB 1:200 - 1:2000 |
分子量 | Detects a band of approximately 140-160kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1). |
阳性对照 | Mouse brain,Rat heart,Rat brain |
性能 | |
纯化方法 | Affinity purification |
同种型 | IgG |
储存/保存方法 | Store at -20℃. Avoid freeze / thaw cycles. |
存储溶液 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
靶标 | |
背景说明 | Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. |
细胞定位 | Membrane,Single-pass type I membrane protein |
UniProt | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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