Rabbit anti-BHLHB3 Polyclonal Antibody
- BHLHB3抗体,Basic helix-loop-helix domain containing class B3, BHE41_HUMAN, bHLH protein DEC2, bHLHB3, bHLHe41, Class B basic helix loop helix protein 3, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, DEC2, Differentially expressed in chondrocytes protein 2, Enhancer of split and hairy related protein 1, Enhancer-of-split and hairy-related protein 1, hDEC2, Moderately similar to basic-helix loop helix protein M.musculus, SHARP-1,
货号: abs133727
货号-规格 | 货期 | 价格 | 数量 |
abs133727-50ug | 1-2周 | ¥1500.00 | - + |
abs133727-100ug | 1-2周 | ¥2300.00 | - + |

概述 | |
别名 | BHLHB3抗体;Basic helix-loop-helix domain containing class B3, BHE41_HUMAN, bHLH protein DEC2, bHLHB3, bHLHe41, Class B basic helix loop helix protein 3, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, DEC2, Differentially expressed in chondrocytes protein 2, Enhancer of split and hairy related protein 1, Enhancer-of-split and hairy-related protein 1, hDEC2, Moderately similar to basic-helix loop helix protein M.musculus, SHARP-1, |
宿主 | Rabbit |
特异性 | BHLHB3 Antibody detects endogenous levels of total BHLHB3. |
反应种属 | Human;Mouse;Rat |
应用 | WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
分子量 | Predicted molecular weight: 50kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 | A synthesized peptide derived from Human BHLHE41(Accession Q9C0J9), corresponding to amino acid residues Y24-K46. |
性能 | |
浓度 | 1mg/ml |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 | Polyclonal Antibody |
储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
靶标 | |
背景说明 | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. |
组织特异性 | Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney. |
细胞定位 | Nucleus; |
UniProt | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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