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  • Rabbit anti-BHLHB3 Polyclonal Antibody

    • BHLHB3抗体,Basic helix-loop-helix domain containing class B3, BHE41_HUMAN, bHLH protein DEC2, bHLHB3, bHLHe41, Class B basic helix loop helix protein 3, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, DEC2, Differentially expressed in chondrocytes protein 2, Enhancer of split and hairy related protein 1, Enhancer-of-split and hairy-related protein 1, hDEC2, Moderately similar to basic-helix loop helix protein M.musculus, SHARP-1,
    货号: abs133727
    产品说明书
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    货号-规格 货期 价格 数量
    abs133727-50ug 1-2周 ¥1500.00
    - +
    abs133727-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    BHLHB3抗体;Basic helix-loop-helix domain containing class B3, BHE41_HUMAN, bHLH protein DEC2, bHLHB3, bHLHe41, Class B basic helix loop helix protein 3, Class B basic helix-loop-helix protein 3, Class E basic helix-loop-helix protein 41, DEC2, Differentially expressed in chondrocytes protein 2, Enhancer of split and hairy related protein 1, Enhancer-of-split and hairy-related protein 1, hDEC2, Moderately similar to basic-helix loop helix protein M.musculus, SHARP-1,
    宿主
    Rabbit
    特异性
    BHLHB3 Antibody detects endogenous levels of total BHLHB3.
    反应种属
    Human;Mouse;Rat
    应用
    WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 50kD
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthesized peptide derived from Human BHLHE41(Accession Q9C0J9), corresponding to amino acid residues Y24-K46.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
    组织特异性
    Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
    细胞定位
    Nucleus;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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