Rabbit anti-ARHGEF3 Polyclonal Antibody
- ARHGEF3抗体,GEF3; STA3; XPLN
货号: abs118524
货号-规格 | 货期 | 价格 | 数量 |
abs118524-50uL | 1-2周 | ¥1500.00 | - + |

概述 | ||
别名 | ARHGEF3抗体;GEF3; STA3; XPLN | |
宿主 | Rabbit | |
反应种属 | Human, Mouse | |
应用 | WB 1:500 - 1:2000 IHC 1:50 - 1:200 | |
分子量 | Detects a band of approximately 60kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. | |
免疫原 | Recombinant fusion protein containing a sequence corresponding to amino acids 287-526 of human ARHGEF3 (NP_062455.1). | |
阳性对照 | MCF-7,HepG2 | |
性能 | ||
纯化方法 | Affinity purification | |
类型 | Polyclonal Antibody | |
同种型 | IgG | |
储存/保存方法 | Store at -20℃. Avoid freeze / thaw cycles. | |
存储溶液 | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | |
靶标 | ||
背景说明 | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | |
细胞定位 | Cytoplasm | |
UniProt | ||
Western blot analysis of extracts of various cell lines, using ARHGEF3 antibody (abs118524) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 60s. | ||
Immunohistochemistry of paraffin-embedded mouse brain tissue using ARHGEF3 antibody at dilution of 1:100 (40x lens). | ||
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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