Rabbit anti-AKAP8 Polyclonal Antibody
- AKAP8抗体;A kinase (PRKA) anchor protein 8, A kinase anchor protein 8, A kinase anchor protein 95, A kinase anchor protein 95 kDa, A kinase anchor protein 95kDa, A-kinase anchor protein 8, A-kinase anchor protein 95 kDa, AKAP 8, AKAP 95, AKAP-8, AKAP-95, Akap8, AKAP8_HUMAN, AKAP95, DKFZp586B1222,
货号: abs133327
货号-规格 | 货期 | 价格 | 数量 |
abs133327-50ug | 1-2周 | ¥1500.00 | - + |
abs133327-100ug | 1-2周 | ¥2300.00 | - + |

概述 | |
别名 | AKAP8抗体;A kinase (PRKA) anchor protein 8, A kinase anchor protein 8, A kinase anchor protein 95, A kinase anchor protein 95 kDa, A kinase anchor protein 95kDa, A-kinase anchor protein 8, A-kinase anchor protein 95 kDa, AKAP 8, AKAP 95, AKAP-8, AKAP-95, Akap8, AKAP8_HUMAN, AKAP95, DKFZp586B1222, |
宿主 | Rabbit |
特异性 | AKAP8 Antibody detects endogenous levels of total AKAP8. |
反应种属 | Human;Mouse;Rat |
应用 | WB 1:500~1:1000, IHC: 1:50~1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
分子量 | Predicted molecular weight: 76KD |
免疫原 | A synthesized peptide derived from Human AKAP8(Accession O43823), corresponding to amino acid residues Q356-R377. |
性能 | |
浓度 | 1mg/ml |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 | Polyclonal Antibody |
储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
靶标 | |
背景说明 | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). |
组织特异性 | Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells. |
翻译后修饰 | Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes. |
细胞定位 | Golgi apparatus;Mitochondrion;Nucleus; |
UniProt | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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