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  • Rabbit anti-AKAP8 Polyclonal Antibody

    • AKAP8抗体;A kinase (PRKA) anchor protein 8, A kinase anchor protein 8, A kinase anchor protein 95, A kinase anchor protein 95 kDa, A kinase anchor protein 95kDa, A-kinase anchor protein 8, A-kinase anchor protein 95 kDa, AKAP 8, AKAP 95, AKAP-8, AKAP-95, Akap8, AKAP8_HUMAN, AKAP95, DKFZp586B1222,
    货号: abs133327
    产品说明书
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    货号-规格 货期 价格 数量
    abs133327-50ug 1-2周 ¥1500.00
    - +
    abs133327-100ug 1-2周 ¥2300.00
    - +
    大包装询价
    概述
    别名
    AKAP8抗体;A kinase (PRKA) anchor protein 8, A kinase anchor protein 8, A kinase anchor protein 95, A kinase anchor protein 95 kDa, A kinase anchor protein 95kDa, A-kinase anchor protein 8, A-kinase anchor protein 95 kDa, AKAP 8, AKAP 95, AKAP-8, AKAP-95, Akap8, AKAP8_HUMAN, AKAP95, DKFZp586B1222,
    宿主
    Rabbit
    特异性
    AKAP8 Antibody detects endogenous levels of total AKAP8.
    反应种属
    Human;Mouse;Rat
    应用
    WB 1:500~1:1000, IHC: 1:50~1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 76KD
    免疫原
    A synthesized peptide derived from Human AKAP8(Accession O43823), corresponding to amino acid residues Q356-R377.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity).
    组织特异性
    Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
    翻译后修饰
    Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases; multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes.
    细胞定位
    Golgi apparatus;Mitochondrion;Nucleus;
    UniProt
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