Rabbit anti-AKAP10 Polyclonal Antibody

AKAP10抗体;1500031L16Rik, A kinase (PRKA) anchor protein 10, A kinase anchor protein 10, A kinase anchor protein 10 mitochondrial, A-kinase anchor protein 10, AKA10_HUMAN, akap 10, AKAP-10, AKAP10, B130049N18Rik, D AKAP 2, D-AKAP-2, dakap 2, dakap2, Dual specific A kinase anchoring protein 2, Dual specificity A kinase-anchoring protein 2, mgc9410, MGC9414|, Mitochondrial A kinase PPKA anchor protein 10, mitochondrial, prka 10, PRKA10, Protein A kinase anchoring protein 10, Protein A kinase anchoring protein 10 mitochondrial precursor, Protein kinase A anchoring protein 10, Protein kinase A-anchoring protein 10,

Rabbit

AKAP10 Antibody detects endogenous levels of total AKAP10.

Human;Mouse;Rat

WB 1:500~1:1000, ELISA(peptide) 1:20000-1:40000

Predicted molecular weight: 73KD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

A synthesized peptide derived from Human AKAP10(Accession O43572), corresponding to amino acid residues R16-K45.

1mg/ml

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .

Polyclonal Antibody

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).

Cytosol;Mitochondrion;Plasma Membrane;