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  • Rabbit anti-AIRE Polyclonal Antibody

    促销商品
    • AIRE抗体,AIRE, AIRE_HUMAN, AIRE1, APECED, APECED protein, APS1, APSI, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator, Autoimmune regulator protein, PGA1,
    货号: abs133328
    产品说明书
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    货号-规格 货期 价格 数量
    abs133328-50ug 1-2周 ¥1500.00 ¥1050.00
    - +
    abs133328-100ug 1-2周 ¥2300.00 ¥1610.00
    - +
    大包装询价
    概述
    别名
    AIRE抗体;AIRE, AIRE_HUMAN, AIRE1, APECED, APECED protein, APS1, APSI, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator, Autoimmune regulator protein, PGA1,
    宿主
    Rabbit
    特异性
    AIRE Antibody detects endogenous levels of total AIRE.
    反应种属
    Human;Mouse
    应用
    WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    分子量
    Predicted molecular weight: 60KD
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
    免疫原
    A synthesized peptide derived from Human AIRE(Accession O43918), corresponding to amino acid residues P116-A144.
    性能
    浓度
    1mg/ml
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4+ T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).
    组织特异性
    Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
    翻译后修饰
    Phosphorylated. Phosphorylation could trigger oligomerization.
    细胞定位
    Nucleus;
    UniProt
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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