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  • RA-9

    货号: abs819654
    CAS号: 919091-63-7
    分子式: C19H15N3O5
    分子量: 365.34
    产品说明书
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    货号-规格 货期 价格 数量
    abs819654-100mg 1-2周 ¥2678.00
    - +
    abs819654-250mg 1-2周 ¥6143.00
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    大包装询价
    产品描述
    描述
    RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    生物活性
    In vitro(体外研究)
    RA-9 (10-30 μM; 48 hours) inhibits growth of ovarian cancer cell lines and primary cultures. RA-9 (1.25-5 μM; 18 hours) causes cell cycle arrest and caspase-mediated apoptosis in ovarian cancer cells. RA-9 (5 μM; 0-24 hours) induces ER-stress responses in ovarian cancer cell. RA-9 (5 μM; over 24 hours) results with time-dependent accumulation of the cleaved formed of PARP noticeable as early as 8 hours.
    In vivo(体内研究)
    RA-9 (5 mg/kg; i.p; one-day on, two-days off) inhibits human ovarian cancer cell growth in vivo and prolongs survival in a mouse model for ovarian cancer.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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