首页 产品中心
  • R-428

    • R-428; R 428,BGB-324,BGB 324
    货号: abs810235
    CAS号: 1037624-75-1
    分子式: C30H34N8
    分子量: 506.64
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810235-5mg 1-2周 ¥1884.00
    - +
    abs810235-10mg 1-2周 ¥3287.00
    - +
    abs810235-50mg 1-2周 ¥16253.00
    - +
    abs810235-100mg 1-2周 ¥26295.00
    - +
    大包装询价
    产品描述
    描述
    R428 is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    R-428; R 428,BGB-324,BGB 324
    外观
    Powder
    可溶性/溶解性
    DMSO 6 mg/mL warmed (11.84 mM)



    5% DMSO+Corn oil 1mg/mL



    生物活性
    靶点
    Axl
    In vitro(体外研究)
    R428 blocks the catalytic and procancerous activities of Axl. R428 inhibits Axl with low nanomolar activity and blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. In a recent study, the Axl inhibitor R428 shows a mean IC50 dose of ∼ 2.0μM for the primary CLL B cells after 24 hours of treatment and normal B-, T-, and natural killer (NK) cells show no significant amount of cell death at this dose of R428 (2.5 μM) under similar experimental conditions.
    In vivo(体内研究)
    Pharmacologic investigations reveal favorable exposure after oral administration such that R428-treated tumors display a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibits angiogenesis in corneal micropocket and tumor models. R428 administration reduces metastatic burden and extends survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
      0 张,还能上传 8 提交
          提示: 尊敬的客户您好,如果您对我们的产品有什么疑问或想要了解的,可以点击“我要咨询”按钮填写您的疑问。
          提交不成功?请联系info@absin.cn。
          我要咨询

      促销资讯 更多

        订购信息
        您可以从我们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
        GO
        • 0