R-428
- R-428; R 428,BGB-324,BGB 324
货号: abs810235
货号-规格 | 货期 | 价格 | 数量 |
abs810235-5mg | 1-2周 | ¥1884.00 | - + |
abs810235-10mg | 1-2周 | ¥3287.00 | - + |
abs810235-50mg | 1-2周 | ¥16253.00 | - + |
abs810235-100mg | 1-2周 | ¥26295.00 | - + |

产品描述 | ||
描述 | R428 is a potent and selective small-molecule inhibitor(IC50=14 nM), blocks the activities of Axl. | |
纯度 | >98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | R-428; R 428,BGB-324,BGB 324 | |
外观 | Powder | |
可溶性/溶解性 | DMSO 6 mg/mL warmed (11.84 mM) 5% DMSO+Corn oil 1mg/mL | |
生物活性 | ||
靶点 | Axl | |
In vitro(体外研究) | R428 blocks the catalytic and procancerous activities of Axl. R428 inhibits Axl with low nanomolar activity and blocks Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. In a recent study, the Axl inhibitor R428 shows a mean IC50 dose of ∼ 2.0μM for the primary CLL B cells after 24 hours of treatment and normal B-, T-, and natural killer (NK) cells show no significant amount of cell death at this dose of R428 (2.5 μM) under similar experimental conditions. | |
In vivo(体内研究) | Pharmacologic investigations reveal favorable exposure after oral administration such that R428-treated tumors display a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibits angiogenesis in corneal micropocket and tumor models. R428 administration reduces metastatic burden and extends survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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