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  • Pyrrolidinedithiocarbamate ammonium
  • 吡咯烷二硫代甲酸铵; Ammonium pyrrolidinedithiocarbamate; APDC;1-Pyrrolidinedithiocarboxylic acid ammonium salt;PDTC
  • 货号: abs814766
    CAS号: 5108-96-3
    分子式: C5H12N2S2
    分子量: 164.29
    产品说明书
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    货号-规格 货期 价格 数量
    abs814766-100mg 现货 ¥525.00
    - +
    abs814766-500mg 1-2周 ¥893.00
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    大包装询价
    产品描述
    描述

    Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
    基本信息
    别名
    吡咯烷二硫代甲酸铵; Ammonium pyrrolidinedithiocarbamate; APDC;1-Pyrrolidinedithiocarboxylic acid ammonium salt;PDTC
    外观
    White to off-white Powder
    可溶性/溶解性
    DMSO :32 mg/mL (194.78 mM)

    Water :32 mg/mL (194.78 mM)
    生物活性
    靶点
    NF-κB
    In vitro(体外研究)
    Pretreatment of cells with PDTC (3-1000 mM) dose-dependently attenuate IL-8 production. Furthermore, PDTC (100 mM) suppresses the accumulation of IL-8 mRNA. PDTC inhibites the activation of NF-kB, because PDTC suppresses both NF-kB DNA binding and NF-kB-dependent transcriptional activity. Taken together, our data demonstrate that NF-kB inhibition with PDTC decrease IL-8 production by intestinal epithelial cells.
    In vivo(体内研究)
    The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+PDTC-treated groupⅡ. These findings suggest that suppression of NF-κB activity by PDTC can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. PDTC is useful for the treatment of ulcerative colitis.
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