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  • PS210

    • PS 210
    货号: abs819892
    CAS号: 1221962-86-2
    分子式: C19H15F3O5
    分子量: 380.31
    产品说明书
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    货号-规格 货期 价格 数量
    abs819892-10mg 1-2周 ¥1100.00
    - +
    abs819892-50mg 1-2周 ¥3600.00
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    大包装询价
    产品描述
    描述
    PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    PS 210
    可溶性/溶解性
    DMSO :76 mg/mL (199.84 mM)
    Ethanol :76 mg/mL (199.84 mM)
    生物活性
    靶点
    PDK1
    In vitro(体外研究)
    When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.
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    • 实验方法 实验条件
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