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  • Prochlorperazine dimaleate
    • 丙氯拉嗪;马来酸丙氯拉嗪
    货号: abs813901
    CAS号: 84-02-6
    分子式: C20H24ClN3S.C8H8O8
    分子量: 606.09
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    货号-规格 货期 价格 数量
    abs813901-100mg 1-2周 ¥672.00
    - +
    abs813901-500mg 1-2周 ¥2016.00
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    大包装询价
    产品描述
    描述

    Prochlorperazine dimaleate is a D2 receptor antagonist. Prochlorperazine dimaleate also interacts with 5-HT3 and nAChR. Prochlorperazine dimaleate displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

    纯度
    >98%
    储存/保存方法
    Store at -20°C
    基本信息
    别名
    丙氯拉嗪;马来酸丙氯拉嗪
    外观
    白色至淡黄色固体
    可溶性/溶解性
    Ethanol :2mg/mL(3.3mM)

    Water :15 mg/L (at 24 °C)
    生物活性
    靶点
    D2 receptor
    In vitro(体外研究)
    Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy.
    In vivo(体内研究)
    Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole.
    参考文献
    参考文献
    Prochlorperazine induces central antinociception mediated by the muscarinic system.
    Ghelardini C, et al. Pharmacol Res. 2004 Sep;50(3):351-8. PMID: 15225680.
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