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  • Porcupine-IN-1

    • Porcn inhibitor 1
    货号: abs821468
    CAS号: 2036044-77-4
    分子式: C25H19FN4O
    分子量: 410.44
    产品说明书
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    货号-规格 货期 价格 数量
    abs821468-5mg 1-2周 ¥1350.00
    - +
    abs821468-25mg 1-2周 ¥4050.00
    - +
    大包装询价
    产品描述
    描述
    Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Porcn inhibitor 1
    可溶性/溶解性
    DMSO : ≥ 100 mg/mL (243.64 mM)
    生物活性
    In vitro(体外研究)
    Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcupine-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.
    In vivo(体内研究)
    Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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