Plerixafor 8HCl (AMD3100 8HCl)
- 普乐沙福八盐酸盐
货号: abs812798
货号-规格 | 货期 | 价格 | 数量 |
abs812798-5mg | 现货 | ¥529.00 | - + |
abs812798-10mg | 现货 | ¥686.00 | - + |
abs812798-25mg | 现货 | ¥1234.00 | - + |

产品描述 | ||
描述 | Plerixafor octahydrochloride(AMD3100 8HCl) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 普乐沙福八盐酸盐 | |
外观 | 白色至类白色粉末 | |
可溶性/溶解性 | Water:100 mg/mL (125.87 mM) | |
生物活性 | ||
靶点 | CXCR | |
In vitro(体外研究) | The CXCR4 inhibitor Plerixafor (AMD3100) is a potent inhibitor of CXCL12-mediated chemotaxis (IC50, 5.7 nM) with a potency slightly better than its affinity for CXCR4. Treating the cells with CCX771 or CXCL11 has no effect on CXCL12-mediated MOLT-4 or U937 TEM. In contrast, 10 μM Plerixafor inhibits CXCL12-mediated TEM in both cells lines. Plerixafor (10 μM)-treated cells show a moderate reduction in cell proliferation compared to CXCL12-stimulated cells, which do not reach statistical significance. | |
In vivo(体内研究) | Plerixafor (2 mg/kg) administration to UUO mice exacerbates renal interstitial T cell infiltration, resulting in increased production of the pro-inflammatory cytokines IL-6 and IFN-γ and decreased expression of the anti-inflammatory cytokine IL-10. Both perivascular and interstitial fibrosis are significantly reduced by the CXCR4 antagonist, Plerixafor (AMD3100) at 8 weeks. LD50, mouse, SC: 16.3 mg/kg; LD50, rat, SC: >50 mg/kg; LD50, mouse and rat, IV injection: 5.2 mg/kg. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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