- 匹美克莫司;SDZ-ASM 981
货号: abs813401
货号-规格 | 货期 | 价格 | 数量 |
abs813401-10mg | 1-2周 | ¥846.00 | - + |
abs813401-25mg | 1-2周 | ¥1654.00 | - + |
abs813401-50mg | 1-2周 | ¥2958.00 | - + |
abs813401-100mg | 1-2周 | ¥5324.00 | - + |

产品描述 | ||
描述 | Pimecrolimus是一种炎性细胞因子分泌物。 | |
纯度 | >98% | |
储存/保存方法 | store at -20℃ for one year(Powder);
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
基本信息 | ||
别名 | 匹美克莫司;SDZ-ASM 981 | |
可溶性/溶解性 | Ethanol :93 mg/mL (114.8 mM)
DMSO :93 mg/mL (114.8 mM) | |
生物活性 | ||
In vitro(体外研究) | Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function. Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin. Pimecrolimus inhibits not only the transcription and synthesis of cytokines from mast cells, but also the release of preformed mediators serotonin and β-hexosaminidase by the inhibition of Fc∈-RI-mediated degranulation and secretion. Pimecrolimus treatment causes a strong down-regulation of the expression of mRNA for genes associated with the macrolactam target pathway and inflammation. | |
In vivo(体内研究) | Pimecrolimus is found to be as effective as cyclosporine A following oral ingestion and slightly superior after subcutaneous administration in mice. Pimecrolimus contrasts cyclosporine A and tacrolimus by inhibiting ongoing secondary inflammatory response, but not impairing the primary immune response in allergic contact dermatitis in mice. Pimecrolimus is as effective as the high-potency corticosteroid clobetasol-17-propionate in a pig model of allergic contact dermatitis (ACD). Pimecrolimus also effectively reduces skin inflammation and pruritus in hypomagnesemic hairless rats, a model that mimics acute signs of atopic dermatitis. Pimecrolimus shows only a low potential to impair systemic immune responses when compared with tacrolimus as shown in rats in (1) the localized graft-versus-host reaction, (2) the antibody formation to sheep red blood cells, and (3) kidney transplantation. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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