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  • Picropodophyllin

    • 苦鬼臼毒素;AXL1717; Picropodophyllotoxin; PPP
    货号: abs817975
    CAS号: 477-47-4
    分子式: C22H22O8
    分子量: 414.41
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    货号-规格 货期 价格 数量
    abs817975-5mg 现货 ¥686.00
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    abs817975-10mg 现货 ¥943.00
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    abs817975-20mg 现货 ¥1521.00
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    abs817975-50mg 现货 ¥3382.00
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    大包装询价
    产品描述
    描述

    Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT).

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    苦鬼臼毒素;AXL1717; Picropodophyllotoxin; PPP
    外观
    白色粉末
    可溶性/溶解性
    DMSO : 76 mg/mL (183.4 mM)

    Ethanol : 1 mg/mL (2.41 mM), warmed
    生物活性
    靶点
    IGF-1R
    In vitro(体外研究)
    In intact cells, PPP efficiently inhibits IGF-1-stimulated IGF-1R, Akt (Ser 473) and Erk1/2 phosphorylation. Picropodophyllin specifically inhibits cell growth, and induces apoptosis in cultured IGF-1R-positive tumor cells. Picropodophyllin synergistically sensitizes HMCL, primary human MM and murine 5T33MM cells to ABT-737 and ABT-199 by further decreasing cell viability and enhancing apoptosis. Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells.
    In vivo(体内研究)
    In SCID mice xenografted with human ES-1, BE, and PC3, Picropodophyllin (20 mg/kg/12 h, i.p.) causes complete tumor regression. In the 5T33MM mouse model, Picropodophyllin also shows a marked antitumor activity, and causes a significant increase in survival.
    参考文献
    参考文献
    [1] Girnita A, et al. Cancer Res. 2004, 64(1), 236-242.
    [2] Economou, M.A., et al. 2008. Invest. Ophthalmol. Vis. Sci. 49: 2620-2626.
    [3] Guha, M., et al. 2007. J. Biol. Chem. 282: 14536-14546.
    [4] Stromberg et al (2006) IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107 669.
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