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  • Phospho-Claspin (Ser30) Rabbit Polyclonal Antibody
  • Claspin; claspin homolog (Xenopus laevis); Claspin homolog; CLSPN; CLSPN protein; CLSPN_HUMAN; hClaspin; Hu Claspin;
  • 货号: abs140084
    产品说明书
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    货号-规格 货期 价格 数量
    abs140084-50ug 1-2周 ¥1100.00
    - +
    abs140084-100ug 1-2周 ¥1650.00
    - +
    大包装询价
    概述
    别名
    Claspin; claspin homolog (Xenopus laevis); Claspin homolog; CLSPN; CLSPN protein; CLSPN_HUMAN; hClaspin; Hu Claspin;
    宿主
    Rabbit
    特异性
    Claspin (Phospho-Ser30) Antibody detects endogenous levels of Claspin only when phosphorylated at Ser30.
    反应种属
    Human
    应用
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    免疫原
    A synthesized peptide derived from human Claspin (Phospho-Ser30).
    性能
    浓度
    1mg/ml
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    类型
    Polyclonal Antibody
    储存/保存方法
    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
    存储溶液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
    靶标
    背景说明
    Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
    组织特异性
    Expression peaks at S/G2 phases of the cell cycle.
    翻译后修饰
    Phosphorylated. Undergoes ATR-dependent phosphorylation by CHEK1 during activation of DNA replication or damage checkpoints. Phosphorylation by CSNK1G1/CK1 promotes CHEK1 binding.Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) during G1 phase, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Following DNA damage, it is deubiquitinated by USP28 in G2 phase, preventing its degradation.
    细胞定位
    Golgi apparatus;Nucleus;
    UniPort
    Western blot analysis Claspin (Phospho-Ser30) using COLO205 whole cell lysates
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