PF-04971729
- Ertugliflozin; PF04971729; PF 04971729
货号： abs811036
| 货号-规格 | 货期 | 价格 | 数量 |
| abs811036-10mg | 1-2周 | ￥2469.00 | - + |
| abs811036-50mg | 1-2周 | ￥6715.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2. | |
| 纯度 | >98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | Ertugliflozin; PF04971729; PF 04971729 | |
| 可溶性/溶解性 | DMSO: ≥ 46 mg/mL | |
| 生物活性 | ||
| 靶点 | hSGLT2 | |
| In vitro(体外研究) | Ertugliflozin (it is claimed) has a 2000-fold increase in selectivity for human SGLT2 over SGLT1 (IC50: SGLT2 = 0.877 nM vs SGLT1 = 1960 nM) in vitro. | |
| In vivo(体内研究) | Ertugliflozin is rapidly absorbed in preclinical species after oral administration, and it is characterized by low clearance (excreted in the urine in preclinical species) and a moderate steady-state distribution volume. There is low potential for pharmacokinetic interaction of ertugliflozin. Ertugliflozin is well absorbed in humans and eliminated largely via glucuronidation. Ertugliflozin improved glycemic control, body weight and blood pressure in patients with T2DM suboptimally controlled by metformin, and is well-tolerated. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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危险品化学品经营许可证(不带存储) 许可证编号：沪(浦)应急管危经许[2022]202585(YS)
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