Abrocitinib
- 阿布罗替尼 , PF-04965842
货号: abs821035
货号-规格 | 货期 | 价格 | 数量 |
abs821035-10mg | 现货 | ¥2450.00 | - + |
abs821035-50mg | 现货 | ¥8190.00 | - + |

产品描述 | ||
描述 | Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease. | |
纯度 | 98% | |
储存/保存方法 | Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. | |
基本信息 | ||
别名 | 阿布罗替尼 ; PF-04965842 | |
外观 | white to beige powder | |
可溶性/溶解性 | DMSO : 125 mg/mL (386.51 mM; Need ultrasonic) | |
生物活性 | ||
In vitro(体外研究) | Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively. | |
In vivo(体内研究) | Abrocitinib (Compound 25; 5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling in rat adjuvant-induced arthritis model. | |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
- 实验方法 实验条件
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