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  • Pergolide mesylate
    • 甲磺酸培高利特;Pergolide methanesulfonate; LY127809
    货号: abs813772
    CAS号: 66104-23-2
    分子式: C19H26N2S.CH4O3S
    分子量: 410.59
    产品说明书
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    货号-规格 货期 价格 数量
    abs813772-5mg 现货 ¥800.00
    - +
    abs813772-10mg 现货 ¥1079.00
    - +
    abs813772-25mg 现货 ¥1943.00
    - +
    abs813772-50mg 现货 ¥3528.00
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    大包装询价
    产品描述
    描述

    Pergolide mesylate(商品名为Permax)是多巴胺受体激动剂,在一些国家用于治疗帕金森病。Pergolide mesylate 作为多巴胺D2,D1,和五羟色胺5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 和5-HT2C受体的激动剂。与Cabergoline类似,Pergolide mesylate在其他多巴胺受体亚型中可能也具有激动活性。

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    甲磺酸培高利特;Pergolide methanesulfonate; LY127809
    外观
    白色固体
    可溶性/溶解性
    DMSO :10 mg/mL
    生物活性
    靶点
    D2 receptor,D1 receptor,5-HT1A,5-HT1B,5-HT2A,,
    In vitro(体外研究)
    Pergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline.
    In vivo(体内研究)
    Pergolide mesylate decreases plasma prolactin concentrations. The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation.
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