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  • PDK1 inhibitor
    • MP7
    货号: abs814288
    CAS号: 1001409-50-2
    分子式: C28H22F2N4O4
    分子量: 516.50
    产品说明书
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    货号-规格 货期 价格 数量
    abs814288-5mg 缺货 询价
    abs814288-10mg 缺货 询价
    abs814288-50mg 缺货 询价
    abs814288-100mg 缺货 询价
    大包装询价
    产品描述
    描述

    MP7 is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    MP7
    外观
    Powder
    可溶性/溶解性
    DMSO : ≥ 100 mg/mL (193.61 mM)
    生物活性
    靶点
    PDK-1
    In vitro(体外研究)
    Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC50 values in the micromolar range.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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