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  • Omecamtiv mecarbil (CK-1827452)
    • CK-1827452, CK1827452,CK 1827452
    货号: abs810613
    CAS号: 873697-71-3
    分子式: C20H24FN5O3
    分子量: 401.43
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810613-5mg 1-2周 ¥1320.00
    - +
    abs810613-10mg 1-2周 ¥2328.00
    - +
    abs810613-50mg 1-2周 ¥7224.00
    - +
    abs810613-100mg 1-2周 ¥10319.00
    - +
    大包装询价
    产品描述
    描述
    Omecamtivmecarbil (CK-1827452) is a specific cardiac myosinactivator and a clinical drug for left ventricular systolic heart failure.
    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    CK-1827452, CK1827452,CK 1827452
    外观
    Powder
    可溶性/溶解性
    DMSO 80 mg/mL (199.28 mM)

    Ethanol 6 mg/mL (14.94 mM)





    生物活性
    靶点
    Myosin ATPase
    In vitro(体外研究)
    In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway.
    In vivo(体内研究)
    Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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