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  • Omaveloxolone (RTA-408)
  • 货号: abs816124
    CAS号: 1474034-05-3
    分子式: C33H44F2N2O3
    分子量: 554.71
    产品说明书
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    货号-规格 货期 价格 数量
    abs816124-5mg 1-2周 ¥1675.00
    - +
    abs816124-25mg 1-2周 ¥5663.00
    - +
    大包装询价
    产品描述
    描述
    Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
    纯度
    99.64 %
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    可溶性/溶解性
    体外:
    DMSO 100mg/mL(180.27mM)
    Ethanol 20mg/mL(36.05mM)
    Water <1mg/mL

    10%DMSO+90%Cornoil 30mg/mL
    生物活性
    靶点
    Nrf2
    In vitro(体外研究)
    RTA 408 potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, RTA 408 inhibits growth with an average GI50 value of 260 nM and induces apoptosis. RTA 408 also inhibits NF-κB and activates JNK in tumor cells.
    In vivo(体内研究)
    In mice with radiation-induced dermatitis, 1.0% RTA 408 markedly reduces epidermal and collagen thickening, prevents dermal necrosis and completely alleviates skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also mitigates hematopoietic acute radiation syndrome in mice.
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