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  • Olanzapine

    促销商品
    • 奥氮平;LY170053
    货号: abs817970
    CAS号: 132539-06-1
    分子式: C17H20N4S
    分子量: 312.44
    产品说明书
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    货号-规格 货期 价格 数量
    abs817970-25mg 现货 ¥309.00 ¥93.00
    - +
    abs817970-100mg 1-2周 ¥827.00
    - +
    大包装询价
    产品描述
    描述

    Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.

    纯度
    >98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    奥氮平;LY170053
    外观
    yellow powder
    可溶性/溶解性
    DMSO : 31.2 mg/mL (100 mM)
    生物活性
    靶点
    5-HT2;D2 receptor
    In vitro(体外研究)
    Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. Olanzapine has a receptor profile that is similar to that of clozapine: it is relatively nonselective at dopamine receptor subtypes and it shows selectivity for mesolimbic and mesocortical over striatal dopamine tracts (electrophysiology; Fos).
    In vivo(体内研究)
    Olanzapine is a potent antagonist at DA receptors (DOPAC levels; pergolide-stimulated increases in plasma corticosterone) and 5-HT receptors (quipazine-stimulated increases in corticosterone), but is weaker at alpha-adrenergic and muscarinic receptors. Olanzapine combined with fluoxetine produces robust, sustained increases of extracellular levels of dopamine ((ex)) and norepinephrine ((ex)) up to 361% and 272% of the baseline in rat prefrontal cortex, respectively, which are significantly greater than either drug alone. Olanzapine at 0.5 mg/kg, 3 mg/kg and 10 mg/kg (s.c.) dose-dependently increases the extracellular dopamine (DA) and norepinephrine (NE) levels in rat prefrontal cortex, nucleus accumbens and striatum. Olanzapine also increases extracellular levels of a DA metabolite, DOPAC, and tissue concentrations of a released DA metabolite, 3-methoxytyramine. Olanzapine results in an 8-11% reduction in mean fresh brain weights as well as left cerebrum fresh weights and volumes in macaque monkeys. Olanzapine results in substantial increases in adiposity: increased total body fat reflecting marked increases in subcutaneous and visceral adipose stores. Olanzapine results in marked hepatic insulin resistance.
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