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  • OAC1
    • OAC1,OAC-1,OAC 1,BAS 00287861
    货号: abs810254
    CAS号: 300586-90-7
    分子式: C14H11N3O
    分子量: 237.26
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810254-5mg 1-2周 ¥764.00
    - +
    abs810254-10mg 1-2周 ¥1152.00
    - +
    abs810254-50mg 1-2周 ¥3918.00
    - +
    abs810254-100mg 1-2周 ¥7051.00
    - +
    大包装询价
    产品描述
    描述
    OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.
    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    OAC1,OAC-1,OAC 1,BAS 00287861
    外观
    Powder
    可溶性/溶解性
    DMSO 47 mg/mL (198.09 mM)

    Ethanol 21 mg/mL (88.51 mM)






    生物活性
    In vitro(体外研究)
    OAC1 at 1 μM enhances reprogramming efficiency by activating both Oct4 and Nanog promoter-driven luciferase reporter genes. Furthermore, OAC1 enhances the pluripotent stem cells (iPSC) reprogramming efficiency and accelerates the reprogramming process in the quartet reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) treated mouse embryonic fibroblasts (MEFs). The iPSC colonies derived using OAC1 along with the quartet factors exhibits typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency via increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. While it doesn’t inhibit the p53-p21 pathway or activate the Wnt-β-catenin signaling. OAC1 may be used to enhance the reprogramming of somatic cells to a pluripotent state.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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