- OAC1,OAC-1,OAC 1,BAS 00287861
货号： abs810254
| 货号-规格 | 货期 | 价格 | 数量 |
| abs810254-5mg | 1-2周 | ￥764.00 | - + |
| abs810254-10mg | 1-2周 | ￥1152.00 | - + |
| abs810254-50mg | 1-2周 | ￥3918.00 | - + |
| abs810254-100mg | 1-2周 | ￥7051.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process. | |
| 纯度 | >98% | |
| 储存/保存方法 | store at -20℃ for one year（Powder）；
in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. | |
| 基本信息 | ||
| 别名 | OAC1,OAC-1,OAC 1,BAS 00287861 | |
| 外观 | Powder | |
| 可溶性/溶解性 | DMSO 47 mg/mL (198.09 mM) Ethanol 21 mg/mL (88.51 mM) | |
| 生物活性 | ||
| In vitro(体外研究) | OAC1 at 1 μM enhances reprogramming efficiency by activating both Oct4 and Nanog promoter-driven luciferase reporter genes. Furthermore, OAC1 enhances the pluripotent stem cells (iPSC) reprogramming efficiency and accelerates the reprogramming process in the quartet reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) treated mouse embryonic fibroblasts (MEFs). The iPSC colonies derived using OAC1 along with the quartet factors exhibits typical ESC morphology, gene-expression pattern, and developmental potential. OAC1 seems to enhance reprogramming efficiency via increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. While it doesn’t inhibit the p53-p21 pathway or activate the Wnt-β-catenin signaling. OAC1 may be used to enhance the reprogramming of somatic cells to a pluripotent state. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
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Certificate of Analysis(COA)
