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  • Nelociguat

    货号: abs819114
    CAS号: 625115-52-8
    分子式: C19H17FN8O2
    分子量: 408.39
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs819114-5mg 1-2周 ¥1940.00
    - +
    abs819114-10mg 1-2周 ¥2999.00
    - +
    大包装询价
    产品描述
    描述
    Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    DMSO: ≥ 105 mg/mL (Need ultrasonic)
    生物活性
    靶点
    Guanylate Cyclase
    In vitro(体外研究)
    Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. Riociguat is metabolized to BAY60-4552 not only via cytochrome P450 isoenzymes 3A4 (CYP3A4), CYP2C8, and CYP2J2, but also via CYP1A1, located in the liver and lungs.
    In vivo(体内研究)
    GSK2181236A and BAY 60-4552 provide partial benefit against hypertension-induced end-organ damage. In spontaneously hypertensive stroke-prone rats, a low dose of BAY 60-4552 decreases urine output and improved survival. A high dose also reduces urine output, and in addition reduces microalbuminuria and attenuates the increase in mean arterial pressure. Both the 0.3 and 3 mg/kg/day doses of BAY 60-4552 improves survival of 46 and 69%. Seven weeks of treatment with BAY 60-4552 (0.3 and 3.0 mg/kg/day) dose-dependently decreases urine output to 79±11 and 56±10 mL/day. BAY 60-4552, and vardenafil provides synergistic beneficial effects and might therefore salvage patients who experience treatment failures with PDE5 inhibitors after radical prostatectomy.
    参考文献
    参考文献
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