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  • NAMI-A

    货号: abs819005
    CAS号: 201653-76-1
    分子式: C5H10Cl4N2ORuS . C3H4N2 . H
    分子量: 458.18
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs819005-1mg 1-2周 ¥2470.00
    - +
    abs819005-5mg 1-2周 ¥6174.00
    - +
    大包装询价
    产品描述
    描述
    NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration.In vitro: NAMI-A can significantly affect tumor cells with metastatic ability.The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. [1] The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397. [2]In vivo: The reference for NAMI-A is 35 mg/kg/day. [1]
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    可溶性/溶解性
    H2O: 8.28 mg/mL
    生物活性
    靶点
    FAK
    参考文献
    参考文献
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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