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  • CKI-7 free base
    • CKI-7
    货号: abs819838
    CAS号: 120615-25-0
    分子式: C11H12ClN3O2S
    分子量: 285.75
    产品说明书
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    货号-规格 货期 价格 数量
    abs819838-5mg 1-2周 ¥1380.00
    - +
    abs819838-10mg 1-2周 ¥2700.00
    - +
    大包装询价
    产品描述
    描述
    CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    CKI-7
    外观
    white solid
    密度
    ~1.4 g/cm3 (Predicted)
    熔点
    188-190° C
    沸点
    ~499.7° C at 760 mmHg (Predicted)
    折射率
    n20D 1.65 (Predicted)
    IC50
    casein kinase Iα: IC50 = 10 µM (human)
    PK值
    pKa: 7.8 (Predicted), pKb: 10.87 (Predicted)
    可溶性/溶解性
    DMSO : 25 mg/mL (87.49 mM; Need ultrasonic)
    生物活性
    In vitro(体外研究)
    CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner. CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.
    In vivo(体内研究)
    In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
    • 实验方法 实验条件
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