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  • Mycro 3

    • Mycro-3
    货号: abs823062
    CAS号: 944547-46-0
    分子式: C24H17ClF2N6O4
    分子量: 526.88
    产品说明书
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    货号-规格 货期 价格 数量
    abs823062-5mg 1-2周 ¥1650.00
    - +
    abs823062-25mg 1-2周 ¥4950.00
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    大包装询价
    产品描述
    描述
    Mycro 3 is potent and selective for c-Myc in whole cell assays.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    Mycro-3
    可溶性/溶解性
    DMSO : ≥ 100 mg/mL (189.80 mM)
    生物活性
    靶点
    c-Myc
    In vitro(体外研究)
    Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 exhibits an excellent specificity with IC50s of 0.25 and 9.0 µM for cells with intact Myc alleles and Myc-null cells, respectively.
    In vivo(体内研究)
    Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells.
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    • 实验方法 实验条件
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