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  • MYCi975

    • NUCC-0200975
    货号: abs819667
    CAS号: 2289691-01-4
    分子式: C25H16Cl2F6N2O2
    分子量: 561.30
    产品说明书
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    货号-规格 货期 价格 数量
    abs819667-5mg 1-2周 ¥2940.00
    - +
    abs819667-25mg 1-2周 ¥7875.00
    - +
    大包装询价
    产品描述
    描述
    MYCi975 (NUCC-0200975) is an orally active MYC inhibitor, which disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 (NUCC-0200975) exhibits potent anti-tumor efficacy with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy.
    纯度
    98%
    储存/保存方法
    Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
    基本信息
    别名
    NUCC-0200975
    可溶性/溶解性
    DMSO :100 mg/mL (178.16 mM)
    生物活性
    靶点
    MYC
    In vitro(体外研究)
    MYCi975 (3 days) inhibits P493-6, MV411, and SK-N-B2 cells viability in an MYC-dependent manner with IC50s of 3.7, 3.9, 6.4 μM, respectively.
    In vivo(体内研究)
    MYCi975 exhibits excellent pharmacokinetic profiles following p.o., i.p., or i.v. administration. The half-lives observed are 7 and 12 hours when dosed at 100 and 250 mg/kg p.o., respectively. The Cmax values attained are 41,533 ng/mL (74 μM) and 54,000 ng/mL (96 μM), respectively. MYCi975 significantly inhibits tumor growth and increases survival in the MycCaP allograft model with animals tolerating a 100 mg/kg/day i.p. dosing for 14 days.
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    • 实验方法 实验条件
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