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  • Motilin (26-47), human, porcine
  • 货号: abs822261
    CAS号: 52906-92-0
    分子式: C120H188N34O35S
    分子量: 2699.07
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs822261-500ug 4周 ¥1764.00
    - +
    abs822261-5mg 4周 ¥12474.00
    - +
    大包装询价
    产品描述
    描述
    Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
    储存/保存方法
    store at -20℃ for one year(Powder)
    基本信息
    可溶性/溶解性
    10 mM in H2O
    生物活性
    靶点
    motilin receptor
    In vitro(体外研究)
    [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM). Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction.
    In vivo(体内研究)
    [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM). Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction.
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