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  • Monomethyl auristatin E (MMAE)
  • MMAE; vedotin;Monomethyl Auristatin E
  • 货号: abs810174
    CAS号: 474645-27-7
    分子式: C39H67N5O7
    分子量: 717.98
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs810174-5mg 1-2周 ¥2125.00
    - +
    abs810174-10mg 1-2周 ¥3581.00
    - +
    abs810174-50mg 1-2周 ¥11435.00
    - +
    abs810174-100mg 1-2周 ¥17199.00
    - +
    大包装询价
    产品描述
    描述

    Monomethyl auristatin E (MMAE; Vedotin) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.

    纯度
    >98%
    储存/保存方法
    store at -20℃ for one year(Powder);
    in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
    基本信息
    别名
    MMAE; vedotin;Monomethyl Auristatin E
    外观
    Powder
    可溶性/溶解性
    DMSO :100 mg/mL (139.27 mM)

    Ethanol :100 mg/mL (139.27 mM)
    生物活性
    靶点
    ADC Cytotoxin
    In vitro(体外研究)
    When coupled to cAC10, MMAE shows selective cytotoxicity in CD30+ cells, and induces G2/M-phase growth arrest and cell death through the induction of apoptosis. When coupled to anti-CD79b antibody, anti–CD79b-vcMMAE has very potent and broad activity across a large panel of NHL cell lines in vitro. When coupled to anti-HER2 antibody, hertuzumab-vc-MMAE can also be effectively internalized and potently kill HER2 over-expressing tumor cells.
    In vivo(体内研究)
    In the Karpas 299 ALCL model, cAC10-vcMMAE (1 mg/kg, i.v.) induces complete, durable tumor regression, while free MMAE (0.36 mg/kg) doesn’t produce detectable antitumor activity. In mouse xenograft models of NHL, anti–CD79b-vcMMAE (7 mg/kg, p.o.) strikingly results in sustained complete tumor remission.
    温馨提示:本产品仅作科研实验使用,不支持临床等研究
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