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  • MKC8866
  • 货号: abs820585
    CAS号: 1338934-59-0
    分子式: C18H19NO7
    分子量: 361.35
    产品说明书
    分享:
    货号-规格 货期 价格 数量
    abs820585-5mg 4周 ¥6930.00
    - +
    abs820585-25mg 4周 ¥22050.00
    - +
    大包装询价
    产品描述
    描述
    MKC8866 is an IRE1 RNase inhibitor with an IC50 of less than 0.1 μM for IRE1α RNase.
    纯度
    98%
    储存/保存方法
    store at -20℃ for one year(Powder)
    生物活性
    In vitro(体外研究)
    Protein folding stress in the endoplasmic reticulum of a cell initiates a signal transduction cascade termed the unfolded protein response or UPR. A key enzyme, inositol requiring enzyme 1 (IRE-1α), relieves protein folding stress by enhancing molecular chaperone activity and therefore protects cells from stress induced apoptosis. MKC8866 is useful for treating at least B cell autoimmune diseases, certain cancers, and some viral infections. MKC8866 (Compound 167) inhibits IRE-1α in the in vitro assay with an IC50 of 50.
    In vivo(体内研究)
    Protein folding stress in the endoplasmic reticulum of a cell initiates a signal transduction cascade termed the unfolded protein response or UPR. A key enzyme, inositol requiring enzyme 1 (IRE-1α), relieves protein folding stress by enhancing molecular chaperone activity and therefore protects cells from stress induced apoptosis. MKC8866 is useful for treating at least B cell autoimmune diseases, certain cancers, and some viral infections. MKC8866 (Compound 167) inhibits IRE-1α in the in vitro assay with an IC50 of 50.
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